The six-member crew of the International Space Station is on the cutting edge of one of the most important discoveries in human history: the first evidence of extraterrestrial life on Mars. As the crew begins to conduct research, their methods end up having unintended consequences and the life form proves more intelligent than anyone ever expected.

Picking up immediately after the events in Resident Evil: Retribution, Alice is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began, The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

An intriguing invitation brings six strangers together. Initially, they think they have gathered for a highly immersive escape room, but they soon make the sickening discovery that they are pawns in a sadistic game of life and death. Together, they move from one terrifying scenario to the next as they find clues and solve puzzles. But the players soon learn that exposing their darkest secrets may hold the key to survive.