When thirteen-year-old Ellie's Grandpa Melvin, a world-renowned scientist in the body of a fourteen-year-old boy, comes for an extended visit, he teaches her that experimenting--and failing--is part of life.

After finally getting a cell phone, Babymouse tries to increase her popularity in middle school by becoming the queen of social media.

Sunny's life becomes confusing when she starts middle school, with her best friend Deb's interests changing to fashion, boys, makeup, and being cool, while Sunny would rather play Dungeons & Dragons with friends.

In the mid-1970s Sunny Lewin is back, star of her personal show, facing the prospect of Middle School, and dealing with the problems of her somewhat dysfunctional family--in particular her older brother, Dale, who has been sent off to a military academy because of his delinquent behavior.

Squish, a meek amoeba who loves the comic book exploits of his favorite hero, Super Amoeba, tries to emulate him when his best friend is threatened by a bully.