Rehabilitating Frankenstein while training a new squad to help recover from an attack by evil vampire Valeri Rusmanov, operator Jamie Carpenter races to recapture escaped prisoners who have been transformed into vampires.

When Jamie Carpenter's mother is kidnapped by strange creatures, he finds himself dragged into Department 19, the government's most secret agency. Fortunately for Jamie, Department 19 can provide the tools he needs to find his mother, and to kill the vampires who want him dead. But unfortunately for everyone, something much older is stirring, something even Department 19 can't stand up against...