Sarah and Nico search for an alchemical cure for a gravely ill friend threatened by an old enemy and a bloodthirsty horseman, while Prince Max tries to explain the strange reappearance of a saint while outmaneuvering a scheming historian.

When students gather at the nation's top high school jazz competition in San Antonio, Texas, the musicians at Xavier Desmond High, teenagers with strange abilities, start going wayward in their efforts to outplay their rivals.