Despite having jobs and men that they love, Tibby, Lena, Carmen, and Bridget know something is missing: the closeness that once sustained them. Carmen is a successful actress in New York, engaged to be married, but misses her friends. Lena finds solace in her art, teaching in Rhode Island, but still thinks of Kostos and the road she didn't take. Bridget lives with her longtime boyfriend, Eric, in San Francisco, and though a part of her wants to settle...

The Sisterhood of the Traveling Pants graduates from high school and spends their last summer before college learning about life and themselves.

As their lives take them in different directions, Lena, Tibby, Carmen, and Bridget discover many more things about themselves and the importance of their relationship with each other.